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Palliative Medicine
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Dextromoramide pharmacokinetics following sublingual administration

TE Jones

Department of Pharmacy, The Queen Elizabeth Hospital

RG Morris

Department of Clinical Pharmacology, The Queen Elizabeth Hospital

NC Saccoia

Department of Clinical Pharmacology, The Queen Elizabeth Hospital

D. Thorne

Palliative Care Unit, The Queen Elizabeth Hospital, Woodville, South Australia

The extent of absorption and other pharmacokinetic parameters of dextromoramide following sublingual administration were assessed in five patients receiving chronic opioid analgesia. The use of the standard 5 mg tablet formulation was associated with negligible absorption in two patients, a prolonged time to peak concentration in the other three and substantial variability in clearance. The study concluded that the standard tablet formulation cannot be recommended for sublingual use where reliable, rapid onset analgesia is required.

Key Words: administration • sublingual • analgesia • analgesics • opioid • dextromoramide • pharmacokinetics

Palliative Medicine, Vol. 10, No. 4, 313-317 (1996)
DOI: 10.1177/026921639601000407
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