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Palliative Medicine
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Stability of morphine sulphate and diamorphine hydrochloride in Intrasite gelTM

Giovambattista Zeppetella

St. Clare Hospice, Hastingwood, Essex

Simon P Joel

Medical Oncology Department, St. Bartholomew's Hospital, London

Maria DC Ribeiro

Peace Hospice, Watford

Several studies have reported that opioids applied topically to painful ulcers produce an analgesic effect. It is unknown whether these opioids (usually mixed with hydrogels) are stable and, if so, for how long. We investigated the stability of morphine sulphate and diamorphine hydrochloride, each mixed with intrasite gel at a concentration of 1.25 mg/mL. Samples were prepared in the laboratory and then stored in plastic containers in the dark, at room temperature, in conditions of normal day/night at room temperature, and at 48C. Aliquots were collected from each container over a 28-day period and analysed using HPLC. No known degradation products were measured in the morphine–intrasite gel mixture stored for up to 28 days, irrespective of the temperature and whether or not samples were exposed to light, suggesting that morphine remains stable. Diamorphine, breaks down to morphine and no other degradation products are measurable.

Key Words: diamorphine • drug stability • intrasite gel • morphine • skin ulcers • topical opioids

Palliative Medicine, Vol. 19, No. 2, 131-136 (2005)
DOI: 10.1191/0269216305pm985oa
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