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Palliative Medicine
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Case report Tamoxifen for retroperitoneal fibrosis

J C Chambers

Katharine House Hospice, East End, Adderbury, Oxon

K McGovern

Lymphoedema Nurse Specialist, Katharine House Hospice, East End, Adderbury, Oxon

Retroperitoneal fibrosis is characterised by diffuse inflammatory proliferation of fibroblasts and the deposition of collagen fibrils throughout the retroperitoneum, especially in perivascular sites. This results in blockage of the ureters and other tubular retroperitoneal structures such as the vasculature and lymphatic channels. Left untreated, it typically follows a progressive and fatal course. The condition responds favourably to tamoxifen and several case reports describe an improvement in renal function on this therapy. This case report describes a subjective and objective functional improvement of lymphoedema secondary to retroperitoneal fibrosis with the use of tamoxifen.

Key Words: fibroblast • lymphodema • retroperitoneal fibrosis • tamoxifen

Palliative Medicine, Vol. 19, No. 2, 163-164 (2005)
DOI: 10.1191/0269216305pm982cr
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