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Palliative Medicine
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The management of xerostomia in patients on haemodialysis: comparison of artificial saliva and chewing gum

Casper P Bots

Henk S Brand

Enno CI Veerman

Marianne Valentijn-Benz

Barbara M Van Amerongen

Arie V Nieuw Amerongen

Department of Dental Basic Sciences, Section Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit and Universiteit van Amsterdam

Robert M Valentijn

Department of Internal Medicine, Rode Kruis Hospital, The Hague

Pieter F Vos

DIANET Dialysis Centres, Utrecht

Joost A Bijlsma

DIANET Dialysis Centres, Amsterdam

Pieter D Bezemer

Department of Clinical Epidemiology and Biostatistics, Vrije Universiteit University Medical Centre, Amsterdam

Piet M ter Wee

Department of Nephrology, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam

Many patients on haemodialysis (HD) therapy suffer from a dry mouth and xerostomia. This can be relieved by mechanical and gustatory stimulation or palliative care. The aim of this crossover study was to investigate the effect and preferences of a sugar-free chewing gum (Freedent WhiteTM) and a xanthan gum-based artificial saliva (XialineTM) in the management of xerostomia in chronic HD patients. Sixty-five HD patients participated in a 6-week crossover trial. The artificial saliva was rated significantly lower than the chewing gum for effectiveness, taste and a global assessment. No preference differences were found for gender and age, although older subjects rated the artificial saliva with a higher mark. Thirty-nine subjects (60%) preferred chewing gum, 15% (n = 10) preferred the artificial saliva. Therefore, both chewing gum and artificial saliva could play an important role in the palliative care of xerostomia in HD patients.

Key Words: artificial saliva • chewing gum • dialysis • palliative care • xerostomia

Palliative Medicine, Vol. 19, No. 3, 202-207 (2005)
DOI: 10.1191/0269216305pm1009oa
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