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Palliative Medicine, Vol. 20, No. 4, 413-418 (2006)
DOI: 10.1191/0269216306pm1145oa

Investigation of diagnostic criteria for cancer-related fatigue syndrome in patients with advanced cancer: a feasibility study

Helen Murphy

Division of Mental Health, St George’s University of London, London, hmurphy{at}sgul.ac.uk

Susanna Alexander

Division of Mental Health, St George’s University of London, London

Patrick Stone

Division of Mental Health, St George’s University of London, London

The primary aim of this study was to explore the feasibility of applying diagnostic criteria for cancer-related fatigue syndrome (CRFS) in patients with advanced cancer. A secondary aim was to assess the use of screening instruments for fatigue and depression in this population. Patients with advanced cancer (n = 16) were interviewed using the Diagnostic Interview for CRFS and a semi-structured psychiatric interview. Subjects also completed the Bi-dimensional Fatigue Scale (BFS) and the Edinburgh Postnatal Depression Scale (EPDS) as screening instruments. The prevalence of psychiatric disorders was 50% (8/16). The EPDS was found to have a sensitivity of 67% and a specificity of 100% for detecting depression. The prevalence of clinically significant fatigue symptoms was 62.5% (10/16). The BFS was found to have a sensitivity of 70% and a specificity of 64% for detecting clinically significant fatigue. The prevalence of CRFS was 12.5% (2/16).

Key Words: depression • diagnosis • fatigue • neoplasms


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[Abstract] [PDF]