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Palliative Medicine
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case-report

Opioid withdrawal syndrome on switching from hydromorphone to alfentanil

F McMunnigall

Haematology Department, Southern General Hospital, 1345 Govan Rd, Glasgow

J Welsh

Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, University of Glasgow, Beatson West of Scotland Cancer Centre

Opioid switching is increasingly practiced. This patient did not tolerate morphine, oxycodone or hydromorphone due to opioid toxicity. Finally switch to alfentanil was performed. The patient developed classical opioid withdrawal symptoms and signs from discontinuation of the hydromorphone. Administration of small aliqouts of this drug reversed the symptoms. The existance of incomplete cross tolerance between  hydromorphone and alfentanil is demonstrated.

Key Words: alfentanil •  hydromorphone • opioid • switching • withdrawal

Palliative Medicine, Vol. 22, No. 2, 191-192 (2008)
DOI: 10.1177/0269216307085391


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