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Palliative Medicine
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0269216308096906v1
22/8/938    most recent
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research-article

Daily symptom burden in end-stage chronic organ failure: a systematic review

DJA Janssen

Central Department of Treatment and Care, Proteion Thuis, Horn daisyjanssen{at}proteion.nl

MA Spruit

Staff functionary of Department of Research, Development and Education, Centre for Integrated Rehabilitation of Organ failure (CIRO), Horn

EFM Wouters

Department of Respiratory Medicine, MUMC, Maastricht; Director of Centre for Integrated Rehabilitation of Organ failure (CIRO), Horn

JMGA Schols

Faculty of Health Medicine and Life sciences, Department of General Practice, University Maastricht, Maastricht

Chronic diseases are nowadays the major cause of morbidity and mortality worldwide. Patients with end-stage chronic organ failure may suffer daily from distressful physical and psychological symptoms. The objective of the present study is to systematically review studies that examined daily symptom prevalence in patients with end-stage chronic organ failure, with attention to those that included patients with either congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) or chronic renal failure (CRF). Thirty-nine articles (8 CHF, 7 COPD, 2 CHF and COPD, 22 CRF) have been included. The included studies used various study designs. There was a wide range of daily symptom prevalence that may be due to the heterogeneity in methodology used. Nevertheless, findings suggest significant symptom burden in these patients. This review highlights the need for further prospective and longitudinal research on symptom prevalence in patients with end-stage CHF, COPD and CRF to facilitate the development of patient-centred palliative care programs.

Key Words: chronic obstructive pulmonary disease • congestive heart failure • chronic kidney failure • palliative care • symptom burden

This version was published on December 1, 2008

Palliative Medicine, Vol. 22, No. 8, 938-948 (2008)
DOI: 10.1177/0269216308096906
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[Abstract] [Full Text] [PDF]

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D. J A Janssen, T. P G Alsemgeest, G. A M Widdershoven, E. F M Wouters, J. M G A Schols, and M. A Spruit
Authors' reply
BMJ, January 9, 2009; 338(jan09_1): b45 - b45.
[Full Text]