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Palliative Medicine
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Sodium naproxen: continuous subcutaneous infusion in neoplastic pain control

Franco Toscani

Sezione di Terapia del Dolore e Cure Palliative, Presidio Ospedaliero Cremonese USSL 51, Cremona

Katia Barosi

Servizio di Farmacia e Farmacologia, Presidio Ospedaliero Cremonese USSL 51, Cremona

Maurizio Scazzina

Presidio Ospedaliero Cremonese USSL 51, Cremona

Sandro Camerini

Servizio di Anestesia e Rlanimazione, Presidio Ospedaliero Cremonese USSL 51, Cremona

Fourteen patients who had been taking naproxen orally (as a single analgesic or in association with morphine, according to the therapeutic drug sequence proposed by WHO) were changed to a subcutaneous continuous infusion of sodium naproxen alone (10 cases) or associated with morphine (4 cases), administered via a portable micro-pump because of the impossibility of taking it orally. All the patients had pain from advanced cancer.

The patients were all monitored with daily checks on the severity and duration of pain, numbers of hours slept, drug use and symptom appearance. Follow-up was continued until death. The same level of analgesia achieved by oral administration was maintained for all patients. In two cases, the presence of a high sodium naproxen and morphine concentration in the same syringe produced a precipitate of morphine which caused an obstruction of the butterfly needle. The administration of sodium naproxen not combined with other drugs in the pump proved a valuable technique, well accepted by the subjects. Its effectiveness appears comparable to oral administration of naproxen.

Key Words: antiflammatory analgesics • naproxen • pain • palliative treatment • parenteral infusion • percutaneous administration

Palliative Medicine, Vol. 3, No. 3, 207-211 (1989)
DOI: 10.1177/026921638900300307
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