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Palliative Medicine
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A pilot study, review of the literature, and dosing guidelines for patient-controlled analgesia using subcutaneous morphine sulphate for chronic cancer pain

T Declan Walsh

Eileen M Smyth

Kathleen Currie

Paul A Glare

Joanne Schneider

Providing effective pain control without side effects is a major challenge in patients with advanced cancer. Oral analgesics may not be practical for a variety of reasons, and several alternatives for parenteral administration are available, including patient-controlled analgesia (PCA). This is a report of a pilot study of the effectiveness, dose requirements, side effects and practicality of continuous subcutaneous morphine infusion delivered by PCA in nine patients. A review of the literature of subcutaneous morphine infusions and guidelines for use are described. Continuous subcutaneous infusion of morphine via a PCA device appears to be a safe and effective method of pain control in patients with advanced cancer.

Key Words: analgesia • infusion pumps • morphine • neoplasms • patient participation • percutaneous administration

Palliative Medicine, Vol. 6, No. 3, 217-226 (1992)
DOI: 10.1177/026921639200600306
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This article has been cited by other articles:


Home page
 AM J HOSP PALLIAT CAREHome page
P. Glare, D. Walsh, and D. Sheehan
The adverse effects of morphine: a prospective survey of common symptoms during repeated dosing for chronic cancer pain.
American Journal of Hospice and Palliative Medicine, May 1, 2006; 23(3): 229 - 235.
[Abstract] [PDF]

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 AM J HOSP PALLIAT CAREHome page
S. B. LeGrand, D. Walsh, K. A. Nelson, and M. P. Davis
A syllabus for fellowship education in palliative medicine
American Journal of Hospice and Palliative Medicine, July 1, 2003; 20(4): 279 - 289.
[Abstract] [PDF]