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Palliative Medicine
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*Compound via MeSH
*Substance via MeSH
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*Cancer
*Intestinal Obstruction
*Nausea and Vomiting
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What's this?

Octreotide in relieving gastrointestinal symptoms due to bowel obstruction

Sebastiano Mercadante

Department of Anaesthesia and Intensive Care, Buccheri La Ferla Hospital, Palermo

Elio Spoldi

Division of Pain Therapy and Palliative Care, National Cancer Institute, Milan

Augusto Caraceni

Division of Pain Therapy and Palliative Care, National Cancer Institute, Milan

Salvatore Maddaloni

Pain Relief and Palliative Care Unit, SAMOT, Palermo, Italy

Maria Teresa Simonetti

Pain Relief and Palliative Care Unit, SAMOT, Palermo, Italy

Gastrointestinal obstruction is a common problem in advanced malignant disease, but its management remains controversial. In those patients for whom surgery is not appropriate, medical intervention is the only remaining option. We present a series of 14 patients with intestinal obstruction who were managed with subcutaneous injections of octreotide, a somatostatin analogue which reduces the volume of gastrointestinal secretions. Good control of vomiting was achieved in 12 patients, and no major side effects were observed. Octreotide would appear to be a useful drug in this clinical situation.

Key Words: intestinal obstruction • neoplasms • octreotide • palliative treatment • vomiting

Palliative Medicine, Vol. 7, No. 4, 295-299 (1993)
DOI: 10.1177/026921639300700406
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