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Palliative Medicine
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Plasma concentrations of midazolam during continuous subcutaneous administration in palliative ca re

Martin D Bleasel

Tasmanian School of Pharmacy, University of Tasmania

Gregory M Peterson

Tasmanian School of Pharmacy, University of Tasmania

Paul F Dunne

Palliative Care Unit, Repatriation General Hospital, Hobart, Tasmania

We have investigated the steady-state plasma concentrations of midazolam during continuous subcutaneous administration in palliative care. Using a sensitive gas chromatography with electron capture detector assay, plasma concentrations of midazolam were measured in 11 patients (median age 68 years; range 47-82 years; six females) receiving the drug by continuous subcutaneous infusion (median rate 20 mg/day; range 10-60 mg/day). While not significant, the infusion rate tended to decrease with increasing age of the patient (Spearman's p = —0.51; p = 0.11). The steady-state plasma concentration range was 10-147 ng/ml, with a median of 30 ng/ml. Infusion rates and plasma concentrations of midazolam were correlated (Spearman's p = 0.71 ; p < 0.05). No other significant relationships were found between plasma concentrations and the variables of age, sex and liver function.

Key Words: infusions • parenteral • midazolam • pharmacokinetics

Palliative Medicine, Vol. 8, No. 3, 231-236 (1994)
DOI: 10.1177/026921639400800307
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