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Palliative Medicine
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0269216309102526v1
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Article

The use of thalidomide in the management of bleeding from a gastric cancer

K Lambert1* and J Ward2

1 Mid Yorkshire Hospitals NHS Trust, Dewsbury and District Hospital, Dewsbury
2 St Gemma's Hospice, Leeds

* To whom correspondence should be addressed.


  Abstract

Medical management of severe gastrointestinal bleeding can present a therapeutic challenge. We describe a case of bleeding secondary to gastric cancer that failed to settle, despite treatment with tranexamic acid, etamsylate and sucralfate. Thalidomide was prescribed for its antiangiogenic properties. Bleeding settled within 1 week of starting 300 mg of thalidomide nocte. The effect appeared to be dose dependant, with bleeding recurring only when the dose was reduced to 100 mg of thalidomide nocte.

Key Words: cancer, gastrointestinal bleeding, thalidomide

First published on March 20, 2009, doi:10.1177/0269216309102526

Palliative Medicine 2009;23:473.

A more recent version of this article appeared on July 1, 2009

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